Immune response during liver-stage parasitic infections

Applicants:

Prof. Dr. Britta Lundström-Stadelmann (Cluster: Neglected Diseases)

Institute of Pathology, UniBE

Prof. Dr. Philippe Krebs (Cluster: Immunity)

Institute of Tissue Medicine and Pathology, UniBE

Prof. Dr. Deborah Stroka (Cluster: Neglected Diseases)

Visceral Surgery and Medicine, Inselspital / Department of Biomedical Research, UniBE

Our project investigates how the liver’s immune system responds to two major parasitic infections, the fox tapeworm and the parasite causing malaria. The liver is the target organ of both parasites and using advanced techniques and animal models, we aim to uncover how the alarmin IL-33 controls liver infection by influencing the host immune system and parasite survival. Our findings will help develop targeted treatments for liver diseases triggered by parasites, especially those impacting poor countries, while fostering scientific collaboration and training at the University of Bern.