Dr. Obdulio García-Nicolás, short biography
Dr. García-Nicolás studied Veterinary Medicine at the University of Murcia, Spain. After earning his degree, he worked for one year as a clinician in a veterinary clinic specialized in exotic animals. Following this, he completed a Master in Scientific and Professional Swine Industry at the University of Murcia, then carrying out a PhD in the research group of Veterinary Histology and Pathologic Anatomy of the same University. During the course of his PhD he spent a total of one year in different institutions including the Animal Health and Veterinary Laboratories Agency, in New Haw, UK; and the Institute of Virology and Immunology (IVI) in Mittelhäusern. In 2014 he joined the research group of Professor Artur Summerfield at the IVI as a postdoctoral fellow, and from 2020 as a Staff Scientist Researcher within the same group. Obdulio was granted a MCID Career Development Grant as co-applicant with Professor Charaf Benarafa in a project entitled “Role of sheep and rodent reservoirs for Wesselsbron, a neglected zoonotic flavivirus”, which began in 2022.
Obdulio has published a number of research articles, including the following selected publications:
Ricklin ME, García-Nicolás O, Brechbühl D, Python S, Zumkehr B, Nougairede A, Charrel RN, Posthaus H, Oevermann A, Summerfield A. 2016. Vector-free transmission and persistence of Japanese encephalitis virus in pigs. Nat Commun. 23;7
García-Nicolás O, Ricklin ME, Liniger M, Vielle NJ, Python S, Souque P, Charneau P, Summerfield A. 2017. A Japanese Encephalitis Virus Vaccine Inducing Antibodies Strongly Enhancing In Vitro Infection Is Protective in Pigs. Viruses. 22;9(5). pii: E124. doi: 10.3390/v9050124
García-Nicolás O, V'kovski P, Vielle NJ, Ebert N, Züst R, Portmann J, Stalder H, Gaschen V, Vieyres G, Stoffel M, Schweizer M, Summerfield A, Engler O, Pietschmann T, Todt D, Alves MP, Thiel V, Pfaender S. 2018. The small compound inhibitor K22 displays broad antiviral activity against different members of the family Flaviviridae and offers potential as pan-viral inhibitor. Antimicrob Agents Chemother. 2018 Sep 4. pii: AAC.01206-18. doi: 10.1128/AAC.01206-18.
García-Nicolás O, Braun RO, Milona P, Lewandowska M, Dijkman R, Alves MP, Summerfield A. 2018. Targeting of the nasal mucosa by Japanese encephalitis virus for nonvector-borne transmission. J Virol. 2018 Oct 3. pii: JVI.01091-18. doi: 10.1128/JVI.01091- 18.
García-Nicolás O, Lewandowska M, Ricklin M, Summerfield A. 2019. Monocyte-derived dendritic cells as model to evaluate species tropism of mosquito-borne flaviviruses. Front Cell Infect Microbiol. doi: 10.3389/fcimb.2019.00005
García-Nicolás O, Godel A, Zimmer G, Summerfield A. Macrophage phagocytosis of SARS-CoV-2-infected cells mediates potent plasmacytoid dendritic cell activation. Cellular & Molecular Immunology. 2023;20(7):835-49.
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